Publications

2024

Kang G, Kim M, Lee Y, Yang H, Seong BL, Jung H. Egg microneedles for transdermal vaccination of inactivated influenza virus. Biomater Sci. 2024 Feb 13;12(4):907-918. 

Kang KR, Kim JA, Cho GW, Kang HU, Kang HM, Kang JH, Seong BL, Lee SY. Comparative Evaluation of Recombinant and Acellular Pertussis Vaccines in a Murine Model. Vaccines (Basel). 2024 Jan 22;12(1). 

Sung J, Cheong Y, Kim YS, Ahn J, Sohn MH, Byun S, Seong BL. Harnessing Pentameric Scaffold of Cholera Toxin B (CTB) for Design of Subvirion Recombinant Dengue Virus Vaccine. Vaccines (Basel). 2024 Jan 17;12(1). 

Park C, Han B, Choi Y, Jin Y, Kim KP, Choi SI, Seong BL. RNA-dependent proteome solubility maintenance in Escherichia coli lysates analysed by quantitative mass spectrometry: Proteomic characterization in terms of isoelectric point, structural disorder, functional hub, and chaperone network. RNA Biol. 2024 Jan;21(1):1-18. 

2023 -2020

Kim JM, Seong BL, Jung J. Highly chromophoric dual-terminus labeling of an intrinsically disordered native eukaryotic protein of interest at nanoscale. Int J Biol Macromol. 2023 Aug 1;245:125396. 

Ahn J, Yu JE, Kim H, Sung J, Han G, Sohn MH, Seong BL. AB(5)-Type Toxin as a Pentameric Scaffold in Recombinant Vaccines against the Japanese Encephalitis Virus. Toxins (Basel). 2023 Jun 29;15(7). 

Shin WJ, Choi S, Seong BL. What are the considerations when selecting a model for influenza drug discovery? Expert Opin Drug Discov. 2023 Jan;18(1):1-3.

Subbbiah J, Oh J, Kim KH, Shin CH, Park BR, Bhatnagar N, Jung YJ, Lee Y, Wang BZ, Seong BL, Kang SM. Thermostable H1 hemagglutinin stem with M2e epitopes provides broad cross-protection against group1 and 2 influenza A viruses. Mol Ther Methods Clin Dev. 2022 Sep 8;26:38-51. 

Oh J, Subbiah J, Kim KH, Park BR, Bhatnagar N, Garcia KR, Liu R, Jung YJ, Shin CH, Seong BL, Kang SM. Impact of hemagglutination activity and M2e immunity on conferring protection against influenza viruses. Virology. 2022 Sep;574:37-46. 

Subbiah J, Oh J, Kim KH, Shin CH, Park BR, Bhatnagar N, Seong BL, Wang BZ, Kang SM. A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine. NPJ Vaccines. 2022 Jun 29;7(1):68. 

Seo SU, Seong BL. Prospects on Repurposing a Live Attenuated Vaccine for the Control of Unrelated Infections. Front Immunol. 2022;13:877845. 

Bhatnagar N, Kim KH, Subbiah J, Park BR, Ko EJ, Seong BL, Kang SM. Comparison of the effects of different potent adjuvants on enhancing the immunogenicity and cross-protection by influenza virus vaccination in young and aged mice. Antiviral Res. 2022 Jan;197:105229.

Park BR, Subbiah J, Kim KH, Kwon YM, Oh J, Kim MC, Shin CH, Seong BL, Kang SM. Enhanced cross protection by hetero prime-boost vaccination with recombinant influenza viruses containing chimeric hemagglutinin-M2e epitopes. Virology. 2022 Jan;566:143-152. 

Kim M, Cheong Y, Lee J, Lim J, Byun S, Jang YH, Seong BL. A Host-Restricted Self-Attenuated Influenza Virus Provides Broad Pan-Influenza A Protection in a Mouse Model. Front Immunol. 2021;12:779223. 

Cheong Y, Kim M, Ahn J, Oh H, Lim J, Chae W, Yang SW, Kim MS, Yu JE, Byun S, Jang YH, Seong BL. Epigallocatechin-3-Gallate as a Novel Vaccine Adjuvant. Front Immunol. 2021;12:769088. 

Lim J, Cheong Y, Kim YS, Chae W, Hwang BJ, Lee J, Jang YH, Roh YH, Seo SU, Seong BL. RNA-dependent assembly of chimeric antigen nanoparticles as an efficient H5N1 pre-pandemic vaccine platform. Nanomedicine. 2021 Oct;37:102438. 

Choi SI, Seong BL. A Conceptual Framework for Integrating Cellular Protein Folding, Misfolding and Aggregation. Life (Basel). 2021 Jun 24;11(7). 

Jang YH, Seong BL. Immune Responses Elicited by Live Attenuated Influenza Vaccines as Correlates of Universal Protection against Influenza Viruses. Vaccines (Basel). 2021 Apr 7;9(4). 

Hwang BJ, Jang Y, Kwon SB, Yu JE, Lim J, Roh YH, Seong BL. RNA-assisted self-assembly of monomeric antigens into virus-like particles as a recombinant vaccine platform Biomaterials. 2021 Feb;269:120650.

Choi SI, Seong BL. A social distancing measure governing the whole proteome Curr Opin Struct Biol. 2021 Feb;66:104-111.

Chung J, Jung Y, Hong C, Kim S, Moon S, Kwak EA, Hwang BJ, Park SH, Seong BL, Kweon DH, Chung WJ. Filamentous anti-influenza agents wrapping around viruses J Colloid Interface Sci. 2021 Feb 1;583:267-278.

Son A, Horowitz S, Seong BL. Chaperna: linking the ancient RNA and protein worlds RNA Biol. 2021 Jan;18(1):16-23.

Jang YH, Seong BL. Call for a paradigm shift in the design of universal influenza vaccines by harnessing multiple correlates of protection Expert Opin Drug Discov. 2020 Dec;15(12):1441-1455.

Kang TH, Seong BL. Solubility, Stability, and Avidity of Recombinant Antibody Fragments Expressed in Microorganisms Front Microbiol. 2020 Sep 25;11:1927.

Ahn JW, Chang ES, Jung YJ, Kim SR, Seong BL, Ha SH. Characterization of the von Willebrand factor/factor VIII complex produced by a novel purification process Arch Pharm Res. 2020 Jul;43(7):714-723.

Kim YS, Lim J, Sung J, Cheong Y, Lee EY, Kim J, Oh H, Kim YS, Cho NH, Choi S, Kang SM, Nam JH, Chae W, Seong BL. Built-in RNA-mediated chaperone (chaperna) for antigen folding tailored to immunized hosts Biotechnol Bioeng. 2020 Jul;117(7):1990-2007.

Park C, Jin Y, Kim YJ, Jeong H, Seong BL. RNA-binding as chaperones of DNA binding proteins from starved cells Biochem Biophys Res Commun. 2020 Apr 2;524(2):484-489.

Lee H, Kang HY, Cho S, Park S, Kim AY, Jung SY, Seong BL, Lee YM. Causality Assessment Guidelines for Adverse Events Following Immunization with a Focus on Guillain-Barre Syndrome Vaccines (Basel). 2020 Feb 24;8(1):101.

2019 -2015

Chae W, Kim P, Kim H, Cheong YC, Kim YS, Kang SM, Seong BL. Hemagglutinin Quantitative ELISA-based Potency Assay for Trivalent Seasonal Influenza Vaccine Using Group-Specific Universal Monoclonal Antibodies Sci Rep. 2019 Dec 23;9(1):19675.

Jang YH, Seong BL. The Quest for a Truly Universal Influenza Vaccine Front Cell Infect Microbiol. 2019 Oct 10;9:344.

Lee H, Park SY, Clark A, Debellut F, Pecenka C, Kim DS, Kim HM, Kim JH, Cho H, Kim AY, Lee M, Jung SY, Seong BL, Kang HY. Cost-effectiveness analysis of the implementation of a National Immunization Program for rotavirus vaccination in a country with a low rotavirus gastroenteritis-related mortality: A South Korean study Vaccine. 2019 Aug 14;37(35):4987-4995.

Lee HM, Kwon SB, Son A, Kim DH, Kim KH, Lim J, Kwon YG, Kang JS, Lee BK, Byun YH, Seong BL. Cost-effectiveness analysis of the implementation of a National Immunization Program for rotavirus vaccination in a country with a low rotavirus gastroenteritis-related mortality: A South Korean study Int J Mol Sci. 2019 Jun 11;20(11):2847.

Lee Y, Ko EJ, Kim KH, Lee YT, Hwang HS, Jung YJ, Jeeva S, Kwon YM, Seong BL, Kang SM. The efficacy of inactivated split respiratory syncytial virus as a vaccine candidate and the effects of novel combination adjuvants Antiviral Res. 2019 Aug;168:100-108.

Park ES, Byun YH, Park S, Jang YH, Han WR, Won J, Cho KC, Kim DH, Lee AR, Shin GC, Park YK, Kang HS, Sim H, Ha YN, Jae B, Son A, Kim P, Yu J, Lee HM, Kwon SB, Kim KP, Lee SH, Park YM, Seong BL, Kim KH. Co-degradation of interferon signaling factor DDX3 by PB1-F2 as a basis for high virulence of 1918 pandemic influenza EMBO J. 2019 May 15;38(10):e99475.

Kwon SB, Ryu K, Son A, Jeong H, Lim KH, Kim KH, Seong BL, Choi SI. Conversion of a soluble protein into a potent chaperone in vivo Sci Rep. 2019 Feb 25;9(1):2735.

Kwon SB, Yu JE, Kim J, Oh H, Park C, Lee J, Seong BL. Quality Screening of Incorrectly Folded Soluble Aggregates from Functional Recombinant Proteins Int J Mol Sci. 2019 Feb 19;20(4):907.

Chae W, Kim P, Hwang BJ, Seong BL. Universal monoclonal antibody-based influenza hemagglutinin quantitative enzyme-linked immunosorbent assay Vaccine. 2019 Mar 7;37(11):1457-1466.

Kong B, Moon S, Kim Y, Heo P, Jung Y, Yu SH, Chung J, Ban C, Kim YH, Kim P, Hwang BJ, Chung WJ, Shin YK, Seong BL, Kweon DH. Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome Nat Commun. 2019 Jan 14;10(1):185.

Dezhbord M, Lee S, Kim W, Seong BL, Ryu WS. Characterization of the molecular events of covalently closed circular DNA synthesis in de novo Hepatitis B virus infection of human hepatoma cells Antiviral Res. 2019 Mar;163:11-18.

Shin WJ, Seong BL. Novel antiviral drug discovery strategies to tackle drug-resistant mutants of influenza virus strains Expert Opin Drug Discov. 2019 Feb;14(2):153-168.

Lee J, Son A, Kim P, Kwon SB, Yu JE, Han G, Seong BL. RNA-dependent chaperone (chaperna) as an engineered pro-region for the folding of recombinant microbial transglutaminase Biotechnol Bioeng. 2019 Mar;116(3):490-502.

Kwon SB, Yu JE, Park C, Lee J, Seong BL. Nucleic Acid-Dependent Structural Transition of the Intrinsically Disordered N-Terminal Appended Domain of Human Lysyl-tRNA Synthetase Int J Mol Sci. 2018 Oct 3;19(10). pii: E3016.

Lee K, Ko HL, Lee EY, Park HJ, Kim YS, Kim YS, Cho NH, Park MS, Lee SM, Kim J, Kim H, Seong BL, Nam JH. Development of a diagnostic system for detection of specific antibodies and antigens against Middle East respiratory syndrome coronavirus Microbiol Immunol. 2018 Sep;62(9):574-584.

Kim YS, Son A, Kim J, Kwon SB, Kim MH, Kim P, Kim J, Byun YH, Sung J, Lee J, Yu JE, Park C, Kim YS, Cho NH, Chang J, Seong BL. Chaperna-Mediated Assembly of Ferritin-Based Middle East Respiratory Syndrome-Coronavirus Nanoparticles Front Immunol. 2018 May 17;9:1093. D

Kim P, Jang YH, Kwon SB, Lee CM, Han G, Seong BL. Glycosylation of Hemagglutinin and Neuraminidase of Influenza A Virus as Signature for Ecological Spillover and Adaptation among Influenza Reservoirs Viruses. 2018 Apr 7;10(4). pii: E183.

Kwon SB, Kim P, Woo HS, Kim TY, Kim JY, Lee HM, Jang YS, Kim EM, Yong TS, Seong BL. Recombinant adenylate kinase 3 from liver fluke Clonorchis sinensis for histochemical analysis and serodiagnosis of clonorchiasis Parasitology. 2018 Oct;145(12):1531-1539.

Lee YJ, Yu JE, Kim P, Lee JY, Cheong YC, Lee YJ, Chang J, Seong BL. Eliciting unnatural immune responses by activating cryptic epitopes in viral antigens FASEB J. 2018 Sep;32(9):4658-4669.

Lee HJ, Lee CM, Kim K, Yoo JM, Kang SM, Ha GS, Park MK, Choi MA, Seong BL, Lee DE. Purification of antibody fragments for the reduction of charge variants using cation exchange chromatography J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 30;1080:20-26.

Jang YH, Kim JY, Byun YH, Son A, Lee JY, Lee YJ, Chang J, Seong BL. Pan-Influenza A Protection by Prime-Boost Vaccination with Cold-Adapted Live-Attenuated Influenza Vaccine in a Mouse Model Front Immunol. 2018 Feb 1;9:116.

Lee YJ, Lee JY, Jang YH, Seo SU, Chang J, Seong BL. Non-specific Effect of Vaccines: Immediate Protection against Respiratory Syncytial Virus Infection by a Live Attenuated Influenza Vaccine Front Microbiol. 2018 Jan 31;9:83.

Lee YH, Jang YH, Kim YS, Kim J, Seong BL. Evaluation of green tea extract as a safe personal hygiene against viral infections J Biol Eng. 2018 Jan 8;12:1.

Yang SW, Jang YH, Kwon SB, Lee YJ, Chae W, Byun YH, Kim P, Park C, Lee YJ, Kim CK, Kim YS, Choi SI, Seong BL. Harnessing an RNA-mediated chaperone for the assembly of influenza hemagglutinin in an immunologically relevant conformation FASEB J. 2018 May;32(5):2658-2675.

Shin YW, Park DB, Choi MM, Chun JH, Seong BL, Rhie GE. Construction of Luminescence- and Fluorescence-Tagged Burkholderia pseudomallei for Pathogen Tracking in a Mouse Model J Microbiol Biotechnol. 2018 Mar 28;28(3):498-502.

Lim KH, Park ES, Kim DH, Cho KC, Kim KP, Park YK, Ahn SH, Park SH, Kim KH, Kim CW, Kang HS, Lee AR, Park S, Sim H, Won J, Seok K, You JS, Lee JH, Yi NJ, Lee KW, Suh KS, Seong BL, Kim KH. Suppression of interferon-mediated anti-HBV response by single CpG methylation in the 5'-UTR of TRIM22 Gut. 2018 Jan;67(1):166-178.

2014 -2010

Jang YH, Cho SH, Son A, Lee YH, Lee J, Lee KH, Seong BL. High-yield soluble expression of recombinant influenza virus antigens from Escherichia coli and their potential uses in diagnosis  Journal of Virological Methods 2014;196:56-64.

Kim NH, Kang YM, Kim G, Choe PG, Song JS, Lee KH, Seong BL, Park WB, Kim NJ, Oh MD. An open-label, single arm, phase III clinical study to evaluate the efficacy and safety of CJ smallpox vaccine in previously vaccinated healthy adults   Vaccine 2013;31:45:5239-5242.

Jang YH, Byun YH, Lee KH, Park ES, Lee YH, Lee YJ, Lee J., Kim KH, Seong BL. Host Defense Mechanism-Based Rational Design of Live Vaccine PLoS ONE 2013;8:10:e75043.

Song JM, Seong BL.   Anti-Influenza Viral Activity of Catechins and Derivatives Tea in Health and Disease Prevention 2013;1185-1193.

Jang YH, Jung EJ, Byun YH, Lee KH, Lee EY, Lee YJ, Seong BL. Immunogenicity and protective efficacy of cold-adapted X-31 live attenuated pre-pandemic H5N1 influenza vaccines Vaccine 2013;31:33:3339-3346.

Park JK, Lee DH, Youn HN, Kim MS, Lee YN, Yuk SS, Lim TH, Jang JH, Kwon JH, Kim BY, Kang SM, Seong BL, Lee JB, Park SY, Choi IS, Song CS. Protective efficacy of crude virus-like particle vaccine against HPAI H5N1 in chickens and its application on DIVA strategy  Influenza and other Respiratory Viruses 2013;7:3:340-348.

Shin WJ, Seong BL. Recent advances in pharmacophore modeling and its application to anti-influenza drug discovery  Expert Opinion on Drug Discovery 2013;8:4:411-426.

Lee DH, Park JK, Kwon JH, Yuk SS, Erdene-Ochir TO, Jang YH, Seong BL, Lee JB, Park SY, Choi IS, Song CS.  Efficacy of Single Dose of a Bivalent Vaccine Containing Inactivated Newcastle Disease Virus and Reassortant Highly Pathogenic Avian Influenza H5N1 Virus against Lethal HPAI and NDV Infection in Chickens  PLoS ONE 2013;8:3:e58186.

Jang YH, Seong BL.  Cross-protective immune responses elicited by live attenuated influenza vaccines Yonsei Medical Journal  2013;54:2:271-282.

Jang YH, Byun YH, Lee DH, Lee KH, Lee YJ, Lee YH, Park JK, Song CS, Seong BL. Cold-adapted X-31 live attenuated 2009 pandemic H1N1 influenza vaccine elicits protective immune responses in mice and ferrets  Vaccine  2013;31:9:1320-1327.

Feng E, Shin WJ, Zhu X, Li J, Ye D., Wang J, Zheng M, Zuo JP, No KT, Liu X, Zhu W, Tang W, Seong BL, Jiang H, Liu H.  Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors Journal of Medicinal Chemistry 2013;56:3:671-684.

Ye D, Shin WJ, Li N, Tang W, Feng E, Li J, He PL, Zuo JP, Kim H, Nam KY, Zhu W, Seong BL, Tai No K, Jiang H, Liu H.  Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities  European Journal of Medicinal Chemistry 2012;54:764-770.

Choi SI, Son A, Lim KH, Jeong H, Seong BL  Macromolecule-assisted de novo protein folding International Journal of Molecular Sciences 2012;13:8:10368-10386

Park HJ., Ferko B, Byun YH, Song JH, Han GY, Roethl E, Egorov A, Muster T, Seong BL, Kweon MN, Song M, Czerkinsky C, Nguyen HH.   Sublingual immunization with a live attenuated influenza A virus lacking the nonstructural protein 1 induces broad protective immunity in mice PLoS ONE 2012;7:6:e39921.

Jang YH, Byun YH, Lee YJ, Lee YH, Lee KH, Seong BL. Cold-Adapted Pandemic 2009 H1N1 influenza virus live vaccine elicits cross-reactive immune responses against Seasonal and H5 influenza A viruses  Journal of Virology 2012;86:10:5953-5958.

Shin WJ, Kim YK, Lee KH, Seong BL.  Evaluation of the antiviral activity of a green tea solution as a hand-wash disinfectant  Bioscience, Biotechnology and Biochemistry 2012;76:3:581-584.

Hong SH, Byun YH, Nguyen CT, Kim SY, Seong BL, Park S, Woo GJ, Yoon Y, Koh JT, Fujihashi K, Rhee JH, Lee SE.  Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infection  Vaccine  2012;30:2:466-474.

Lee HJ, Lee YN, Youn HN, Lee DH, Kwak JH, Seong BL, Lee JB, Park SY, Choi IS, Song CS. Immunology, health, and disease, anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens Poultry Science 2012;91:1:66-73.

Shim, BS, Choi YK, Yun CH, Lee EG, Jeon YS, Park SM, Cheon IS, Joo DH, Cho CH, Song MS, Seo SU, Byun YH, Park HJ, Poo H, Seong BL, Kim JO, Nguyen HH, Stadler K, Kim DW, Hong KJ, Czerkinsky C, Song MK.  Sublingual immunization with M2-based vaccine induces broad protective immunity against influenza PLoS ONE  2011;6:11:e27953.

Lim KH, Kim KH, Choi SI, Park ES, Park SH, Ryu K, Park YK, Kwon SY, Yang SI, Lee HC, Sung IK, Seong BL. RPS3a over-expressed in HBV-associated hepatocellular carcinoma enhances the HBx-induced NF-κB signaling via its novel chaperoning function PLoS ONE  2011;6:8:e22258.

Nam JS, Kim AR, Yoon JC, Byun YH, Kim SA, Kim KR, Cho S, Seong BL, Ahn CW, Lee JM. The humoral immune response to the inactivated influenzaA (H1N1) 2009 monovalent vaccine in patients with Type2 diabetes mellitus in Korea  Diabetic Medicine 2011;28:7:815-817.

Choi SI, Lim KH, Seong BL.  Chaperoning roles of macromolecules interacting with proteins in vivo International Journal of Molecular Sciences 2011;12:3:1979-1990.

Seo SU, Kwon HJ, Ko HJ, Byun YH, Seong BL, Uematsu S, Akira S, Kweon MN. Type I interferon signaling regulates Ly6Chi monocytes and neutrophils during acute viral pneumonia in mice  PLoS Pathogens 2011;7:2:e1001304

Seo SU, Kwon HJ, Song JH, Byun, YH, Seong BL, Kawai T, Akira S, Kweon MN. MyD88 signaling is indispensable for primary influenza A virus infection but dispensable for secondary infection Journal of Virology 2010;84:24:12713-12722.

Kim KH, Kim ND, Seong, BL. Discovery and development of anti-HBV agents and their resistance Molecules 2010;15:9:5878-5908.

Jang HC, Kim CJ, Kim KH, Lee KH, Byun YH, Seong BL, Saletti G, Czerkinsky C, Park WB, Park SW, Kim HB, Kim NJ, Oh MD.  A randomized, double-blind, controlled clinical trial to evaluate the efficacy and safety of CJ-50300, a newly developed cell culture-derived smallpox vaccine, in healthy volunteers Vaccine 2010;28:36:5845-5849.

Ryu K, Kim KH, Yoo SY, Lee EY, Lim KH, Min MK, Kim H, Choi SI, Seong BL.  Production and characterization of active hepatitis C virus RNA-dependent RNA polymerase. Protein Expr Purif  2010.

Shin WJ, Lee KH, Park MH, Seong BL.  Broad-spectrum antiviral effect of Agrimonia pilosa extract on influenza viruses. Microbiol Immunol  2010; 54: 11-19.

Jung EJ, Lee KH, Seong BL.  Reverse genetic platform for inactivated and live-attenuated influenza vaccine. Exp Mol Med  2010; 42: 116-121.

Kim HK, Choi SI, Seong BL.  5S rRNA-assisted DnaK refolding. Biochem Biophys Res Commun  2010; 391: 1177-1181.

2009 -2005

Lee EY, Lee KH, Jung EJ, Jang YH, Seo SU, Kim HA, Seong BL.  Genotyping and screening of reassortant live-attenuated influenza B vaccine strain. J Virol Methods  2009

Park KS, Lee J, Ahn SS, Byun YH, Seong BL, Baek YH, Song MS, Choi YK, Na YJ, Hwang I, Sung YC, Lee CG.  Mucosal immunity induced by adenovirus-based H5N1 HPAI vaccine confers protection against a lethal H5N2 avian influenza virus challenge. Virology  2009; 395: 182-189.

Ryu K, Kim ND, Choi SI, Han CK, Yoon JH, No KT, Kim KH, Seong BL.  Identification of novel inhibitors of HCV RNA-dependent RNA polymerase by pharmacophore-based virtual screening and in vitro evaluation. Bioorg Med Chem  2009; 17: 2975-2982.

Choi SI, Ryu K, Seong BL.  RNA-mediated chaperone type for de novo protein folding. RNA Biol  2009; 6: 21-24.

Choi SI, Han KS, Kim CW, Ryu KS, Kim BH, Kim KH, Kim SI, Kang TH, Shin HC, Lim KH, Kim HK, Hyun JM, Seong BL.  Protein solubility and folding enhancement by interaction with RNA. PLoS One  2008; 3: e2677.

Ryu K, Kim CW, Kim BH, Han KS, Kim KH, Choi SI, Seong BL.  Assessment of substrate-stabilizing factors for DnaK on the folding of aggregation-prone proteins. Biochem Biophys Res Commun  2008; 373: 74-79.

Song JM, Lee YJ, Jeong OM, Kang HM, Kim HR, Kwon JH, Kim JH, Seong BL, Kim YJ. Generation and evaluation of reassortant influenza vaccines made by reverse genetics for H9N2 avian influenza in Korea. Vet Microbiol  2008; 130: 268-276.

Seo SU, Byun YH, Lee EY, Jung EJ, Jang YH, Kim HA, Ha SH, Lee KH, Seong BL. Development and characterization of a live attenuated influenza B virus vaccine candidate. Vaccine  2008; 26: 874-881.

Park SA, Song ES, Cho YJ, Ahn BY, Ha SH, Seong BL, Lee KH, Lee NG.  Immune responses of mice to influenza subunit vaccine in combination with CIA07 as an adjuvant. Microbiol Immunol  2007; 51: 1099-1107.

Seo SU, Lee KH, Byun YH, Kweon MN, Seong BL.  Immediate and broad-spectrum protection against heterologous and heterotypic lethal challenge in mice by live influenza vaccine. Vaccine  2007; 25: 8067-8076.

Song JM, Park KD, Lee KH, Byun YH, Park JH, Kim SH, Kim JH, Seong BL.  Biological evaluation of anti-influenza viral activity of semi-synthetic catechin derivatives. Antiviral Res  2007; 76: 178-185.

Song JM, Seong BL.  Tea catechins as a potential alternative anti-infectious agent. Expert Rev Anti Infect Ther  2007; 5: 497-506.

Kim CW, Han KS, Ryu KS, Kim BH, Kim KH, Choi SI, Seong BL.  N-terminal domains of native multidomain proteins have the potential to assist de novo folding of their downstream domains in vivo by acting as solubility enhancers. Protein Sci  2007; 16: 635-643.

Kim do Y, Kim KH, Kim ND, Lee KY, Han CK, Yoon JH, Moon SK, Lee SS, Seong BL.  Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin. J Med Chem  2006; 49: 5664-5670.

Kim K, Lee M, Park H, Kim JH, Kim S, Chung H, Choi K, Kim IS, Seong BL, Kwon IC.  Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging. J Am Chem Soc  2006; 128: 3490-3491.

Ha SH, Kim HA, Kim YH, Kim JS, Lee KH, Park SY, Park WJ, Seong BL.  A multiplex RT-PCR method for screening of reassortant live influenza vaccine virus strains. J Virol Methods  2006; 134: 154-163.

Lee KH, Seo SU, Song JM, Lee CM, Kim HA, Seong BL.  Characterization of live influenza vaccine donor strain derived from cold-adaptation of X-31 virus. Vaccine  2006; 24: 1966-1974.

Han KS, Kim SI, Choi SI, Seong BL. N-Glycosylation of secretion enhancer peptide as influencing factor for the secretion of target proteins from Saccharomyces cerevisiae. Biochem Biophys Res Commun  2005; 337: 557-562.

Song JM, Lee KH, Seong BL.  Antiviral effect of catechins in green tea on influenza virus. Antiviral Res  2005; 68: 66-74.

Park KS, Seol W, Yang HY, Lee SI, Kim SK, Kwon RJ, Kim EJ, Roh YH, Seong BL, Kim JS. Identification and use of zinc finger transcription factors that increase production of recombinant proteins in yeast and mammalian cells. Biotechnol Prog  2005; 21: 664-670. 

2004 -2000

Kim KH, Lee KH, Chang HY, Ahn SH, Tong S, Yoon YJ, Seong BL, Kim SI, Han KH. Evolution of hepatitis B virus sequence from a liver transplant recipient with rapid breakthrough despite hepatitis B immune globulin prophylaxis and lamivudine therapy. J Med Virol  2003; 71: 367-375.

Kim KH, Seong BL.  Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal. EMBO J  2003; 22: 2104-2116.

Park KS, Ahn Y, Kim JA, Yun MS, Seong BL, Choi KY.  Extracellular zinc stimulates ERK-dependent activation of p21(Cip/WAF1) and inhibits proliferation of colorectal cancer cells. Br J Pharmacol  2002; 137: 597-607.

Lee KY, Seong BL, Kim K.  Soluble factor-mediated differentiation of CD4+CD8+ thymocytes to single positives in vitro. Differentiation  2002; 70: 410-421.

Lee KY, Hyeok Yoon JH, Kim M, Roh S, Lee YS, Seong BL, Kim K.  A dipalmitoyl peptide that binds SH3 domain, disturbs intracellular signal transduction, and inhibits tumor growth in vivo. Biochem Biophys Res Commun  2002; 296: 434-442.

Lee KY, Chun E, Kim NY, Seong BL.  Characterization of HLA-A2.1-restricted epitopes, conserved in both Hantaan and Sin Nombre viruses, in Hantaan virus-infected patients. J Gen Virol  2002; 83: 1131-1136.

Lee KY, Chun E, Seong BL.  Investigation of antigen delivery route in vivo and imune-boosting effects mediated by pH-sensitive liposomes encapsulated with K(b)-restricted CTL epitope. Biochem Biophys Res Commun  2002; 292: 682-688.

Song HW, Choi SI, Seong BL.  Engineered recombinant enteropeptidase catalytic subunit: effect of N-terminal modification. Arch Biochem Biophys  2002; 400: 1-6.

Choi SI, Song HW, Moon JW, Seong BL.  Recombinant enterokinase light chain with affinity tag: expression from Saccharomyces cerevisiae and its utilities in fusion protein technology. Biotechnol Bioeng  2001; 75: 718-724.

Lee KH, Youn JW, Kim HJ, Seong BL.  Identification and characterization of mutations in the high growth vaccine strain of influenza virus. Arch Virol  2001; 146: 369-377.



1999 -1990

Lee J, Choi SI, Jang JS, Jang K, Moon JW, Bae CS, Yang DS, Seong BL.  Novel secretion system of recombinant Saccharomyces cerevisiae using an N-terminus residue of human IL-1 beta as secretion enhancer. Biotechnol Prog  1999; 15: 884-890.

Bae CS, Yang DS, Chang KR, Seong BL, Lee J.  Enhanced secretion of human granulocyte colony-stimulating factor directed by a novel hybrid fusion peptide from recombinant Saccharomyces cerevisiae at high cell concentration. Biotechnol Bioeng  1998; 57: 600-609.

Lee SW, Youn JW, Seong BL, Sung YC.  IL-6 induces long-term protective immunity against a lethal challenge of influenza virus. Vaccine  1999; 17: 490-496.

Cheong HK, Cheong C, Lee YS, Seong BL, Choi BS.  Structure of influenza virus panhandle RNA studied by NMR spectroscopy and molecular modeling. Nucleic Acids Res  1999; 27: 1392-1397.

Lee KH, Seong BL.  The position 4 nucleotide at the 3' end of the influenza virus neuraminidase vRNA is involved in temporal regulation of transcription and replication of neuraminidase RNAs and affects the repertoire of influenza virus surface antigens. J Gen Virol  1998; 79 ( Pt 8): 1923-1934.

Lee YS, Seong BL.  Nucleotides in the panhandle structure of the influenza B virus virion RNA are involved in the specificity between influenza A and B viruses. J Gen Virol  1998; 79 ( Pt 4): 673-681.

Kim HJ, Fodor E, Brownlee GG, Seong BL.  Mutational analysis of the RNA-fork model of the influenza A virus vRNA promoter in vivo. J Gen Virol  1997; 78 ( Pt 2): 353-357.

Lee YS, Seong BL.  Mutational analysis of influenza B virus RNA transcription in vitro. J Virol  1996; 70: 1232-1236.

Pritlove DC, Fodor E, Seong BL, Brownlee GG.  In vitro transcription and polymerase binding studies of the termini of influenza A virus cRNA: evidence for a cRNA panhandle. J Gen Virol  1995; 76 ( Pt 9): 2205-2213.

Fodor E, Seong BL, Brownlee GG.  Photochemical cross-linking of influenza A polymerase to its virion RNA promoter defines a polymerase binding site at residues 9 to 12 of the promoter. J Gen Virol  1993; 74 ( Pt 7): 1327-1333.

Seong BL.  Influencing the influenza virus: genetic analysis and engineering of the negative-sense RNA genome. Infect Agents Dis  1993; 2: 17-24.

Seong BL, Brownlee GG.  Nucleotides 9 to 11 of the influenza A virion RNA promoter are crucial for activity in vitro. J Gen Virol  1992; 73 ( Pt 12): 3115-3124.

Seong BL, Kobayashi M, Nagata K, Brownlee GG, Ishihama A.  Comparison of two reconstituted systems for in vitro transcription and replication of influenza virus. J Biochem  1992; 111: 496-499.

Seong BL, Brownlee GG.  A new method for reconstituting influenza polymerase and RNA in vitro: a study of the promoter elements for cRNA and vRNA synthesis in vitro and viral rescue in vivo. Virology  1992; 186: 247-260.

Varshney U, Lee CP, Seong BL, RajBhandary UL.  Mutants of initiator tRNA that function both as initiators and elongators. J Biol Chem  1991; 266: 18018-18024.

Lee CP, Seong BL, RajBhandary UL.  Structural and sequence elements important for recognition of Escherichia coli formylmethionine tRNA by methionyl-tRNA transformylase are clustered in the acceptor stem. J Biol Chem  1991; 266: 18012-18017.

1989 -1980

Seong BL, Lee CP, RajBhandary UL.  Suppression of amber codons in vivo as evidence that mutants derived from Escherichia coli initiator tRNA can act at the step of elongation in protein synthesis. J Biol Chem  1989; 264: 6504-6508.

Seong BL, RajBhandary UL.  Mutants of Escherichia coli formylmethionine tRNA: a single base change enables initiator tRNA to act as an elongator in vitro. Proc Natl Acad Sci U S A  1987; 84: 8859-8863.

Seong BL, RajBhandary UL.  Escherichia coli formylmethionine tRNA: mutations in GGGCCC sequence conserved in anticodon stem of initiator tRNAs affect initiation of protein synthesis and conformation of anticodon loop. Proc Natl Acad Sci U S A  1987; 84: 334-338.

Seong BL, Son HJ, Mheen TI, Han MH.  Microbial transformation of rifamycin B: a new synthetic approach to rifamycin derivatives. J Antibiot (Tokyo)  1983; 36: 1402-1404.

Han MH, Seong BL, Son HJ, Mheen TI.  Rifamycin B oxidase from Monocillium spp., a new type of diphenol oxidase. FEBS Lett  1983; 151: 36-40.

Park JM, Choi CY, Seong BL, Han MH.  Effect of mass transfer in a recirculation batch reactor system for immobilized penicillin amidase. Biotechnol Bioeng  1982; 24: 2215-2226.

Park JM, Choi CY, Seong BL, Han MH.  The production of 6-aminopenicillanic acid by a multistage tubular reactor packed with immobilized penicillin amidase. Biotechnol Bioeng  1982; 24: 1623-1637.